Mission Mobile Medical Blog

Substance Use Treatment During Pregnancy

Written by Mollie Williams, DrPH, MPH | Jul 3, 2026 1:10:27 AM

Treating substance use disorder during pregnancy means keeping a pregnant patient in evidence-based care, most often medications for opioid use disorder (MOUD), while coordinating prenatal visits, delivery at a hospital or birth center, and postpartum follow-up. For opioid use disorder, the standard of care is methadone or buprenorphine paired with prenatal care and behavioral support. The American College of Obstetricians and Gynecologists (ACOG) supports MOUD as the recommended treatment in pregnancy. Mobile programs have a defined role here. A mobile maternal care program can bring screening, MOUD, and prenatal touchpoints to patients who face distance, stigma, or transportation barriers, and it connects each patient to a delivery hospital.

 

Why does treating substance use in pregnancy matter?

Treating substance use in pregnancy matters because untreated opioid use disorder carries serious risk for the pregnant patient and the newborn, and effective treatment exists. MOUD keeps patients in care, reduces the harms of continued unmanaged use, and creates a stable path through prenatal, delivery, and postpartum periods.

The evidence base for MOUD is strong across the population with opioid use disorder. Agonist medication such as methadone or buprenorphine is associated with roughly a 50% reduction in mortality among people with opioid use disorder. Pregnancy is a period when many patients are motivated to engage, and a program that meets them where they are can turn that motivation into sustained treatment.

 

What is the standard of care?

The standard of care for opioid use disorder in pregnancy is medication for opioid use disorder, specifically methadone or buprenorphine, combined with prenatal care and behavioral support. ACOG recommends MOUD over medically supervised withdrawal, which carries a high risk of return to use.

Methadone requires daily dosing through an opioid treatment program or its mobile component. Buprenorphine can be managed in an outpatient setting without daily visits to an opioid treatment program, which changes what a mobile schedule can look like. A behavioral health satellite clinic network can carry the behavioral and counseling side of care alongside the medication.

 

Are methadone and buprenorphine used during pregnancy?

Both methadone and buprenorphine are accepted treatments in pregnancy, and the choice is individualized. The main difference for the newborn involves neonatal abstinence syndrome. Buprenorphine in pregnancy is associated with less severe neonatal abstinence syndrome, including less morphine needed, a shorter duration of treatment, and a shorter hospital stay, compared with methadone.

Two practical factors follow from this:

  • Buprenorphine can be managed outpatient without daily opioid treatment program visits, which suits many patients served by a mobile program and reduces the daily travel burden.
  • Methadone remains a strong option, and some patients do better on it. When a patient needs methadone, the program coordinates dosing through an opioid treatment program or an approved mobile medication unit.

The right medication is the one that keeps a specific patient in care. A program should support both pathways rather than steer every patient toward one.

 

How do mobile programs help?

Mobile programs help pregnant patients with substance use disorder by lowering three common barriers: access, stigma, and retention. A unit parked at a familiar community site removes the travel and scheduling problems that cause missed appointments, and it separates care from settings a patient may associate with judgment.

Access is a documented problem. As of December 2017, about half of US counties had no buprenorphine prescriber, and nearly a third of rural Americans lived in a county without one, compared with 2.2% of urban Americans. A mobile program brings a prescriber and prenatal touchpoints into that gap. Retention improves when patients can reach care, and pregnancy care depends on regular contact across many weeks. Sound planning and staffing for the mobile program makes that consistency possible.

 

How does the program connect to prenatal care, delivery, and postpartum follow-up?

The program connects care through formal referral relationships and shared communication with a delivery hospital, established before the first patient enrolls. Continuity across settings is the whole point, and it takes planning.

Prenatal care

Mobile prenatal touchpoints supplement, and hand off to, the obstetric team that will manage delivery. The program shares records and coordinates the schedule so a patient is not repeating the same visit in two places.

Delivery

Every enrolled patient has a named delivery hospital or birth center and a warm handoff. The obstetric and pediatric teams know the patient's MOUD status in advance so newborn care, including monitoring for neonatal abstinence syndrome, is planned rather than improvised.

Postpartum follow-up

Postpartum is a high-risk window for returning to use, and it is where many programs lose contact. A mobile unit can hold that connection by continuing MOUD and behavioral support after delivery, on the same community schedule the patient already trusts. A maternal satellite clinic network is built to keep that thread intact.

 

Frequently asked questions

 

Can a mobile clinic deliver a baby?

No. Mobile clinics do not deliver babies. A mobile program supports care around pregnancy, including screening, MOUD, prenatal visits, and postpartum follow-up, and refers each patient to a hospital or birth center for delivery. The program coordinates a warm handoff so the delivery team knows the patient's history and medication in advance.

 

Is medication for opioid use disorder safe in pregnancy?

Medication for opioid use disorder is the standard of care in pregnancy. ACOG supports methadone or buprenorphine over medically supervised withdrawal, which carries a high risk of return to use. The medication keeps the patient in care and is paired with prenatal and behavioral support.

 

Which is better in pregnancy, methadone or buprenorphine?

Both are accepted, and the choice is individualized. Buprenorphine is associated with less severe neonatal abstinence syndrome, including less morphine, shorter treatment, and shorter hospital stay, and it can be managed outpatient without daily opioid treatment program visits. Methadone remains a strong option, and some patients do better on it.

 

Should we staff the mobile program with our fixed-site clinicians?

Hire staff dedicated to the mobile program instead. Rotating fixed-site clinicians onto the unit breaks the community continuity that pregnancy care depends on, and it makes the mobile program the first service cut when a fixed site loses a clinician. Dedicated staff build the trust that keeps patients enrolled across many weeks.

 

If you lead a maternal health, obstetric, or substance use program and want a mobile unit that keeps pregnant patients in MOUD and prenatal care while referring cleanly for delivery, explore how a maternal care satellite clinic network can extend your reach.